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Expression and functional role of inhibitor-of-apoptosis protein livin (BIRC7) in neuroblastoma.
Dasgupta A, Alvarado CS, Xu Z, Findley HW. Dasgupta A, et al. Biochem Biophys Res Commun. 2010 Sep 10;400(1):53-9. doi: 10.1016/j.bbrc.2010.08.001. Epub 2010 Aug 5. Biochem Biophys Res Commun. 2010. PMID: 20691667
We evaluated the expression of the inhibitor-of-apoptosis protein (IAP)livin (BIRC7)in 59 cases ofneuroblastoma (NBL) by quantitative RT-PCR. We also examined the role of livin in protecting tumor cells from chemotherapy drugs. ...Multivariate analysis of prognostic factor …
We evaluated the expression of the inhibitor-of-apoptosis protein (IAP)livin (BIRC7)in 59 cases ofneuroblastoma (NBL) by quantitative …
MycN is a transcriptional regulator of livin in neuroblastoma.
Dasgupta A, Peirce SK, Findley HW. Dasgupta A, et al. Oncol Rep. 2009 Oct;22(4):831-5. doi: 10.3892/or_00000506. Oncol Rep. 2009. PMID: 19724862
Conversely, induction of MycN in neuroblastoma cells with low endogenous levels of MycN and livin protein upregulated livin expression. ...Based on these results, we hypothesize that MycN is required for livin expression and that livin may counteract the proa …
Conversely, induction of MycN in neuroblastoma cells with low endogenous levels of MycN and livin protein upregulated livin ex …
Expression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcome.
Kim DK, Alvarado CS, Abramowsky CR, Gu L, Zhou M, Soe MM, Sullivan K, George B, Schemankewitz E, Findley HW. Kim DK, et al. Pediatr Dev Pathol. 2005 Nov-Dec;8(6):621-9. doi: 10.1007/s10024-005-4108-3. Epub 2005 Nov 18. Pediatr Dev Pathol. 2005. PMID: 16328668
In the NB cases, we further analyzed the correlation between livin expression and clinical and biological features with established prognostic significance (i.e., age at diagnosis, stage, histology, and MYCN oncogene status), and patients' outcome. Livin expression alone d …
In the NB cases, we further analyzed the correlation between livin expression and clinical and biological features with established prognost …